In-Vivo Toxicology Services

Regulatory Toxicity studies

Acute Toxicity Studies

  • Acute oral toxicity in rats (OECD)
  • Acute oral toxicity in mice (OECD)
  • Acute dermal in rats (OECD)
  • Acute Inhalation (OECD)
  • Acute dermal corrosion/Primary skin irritation (OECD, ISO-10993, Indian standards)
  • Guinea Pigs Maximisation test (GPMT)/ Skin sensitization (OECD, ISO-10993)
  • Acute eye irritation test (OECD, ISO-10993)
  • Intracutaneous test (ISO-10993)
  • Systemic I.V, I.P, Oral tests (ISO-10993, USP-39)
  • Muscle implantation in rats in rabbits (ISO-10993, USP-39)
  • Bone implantation in rabbits (ISO-10993, USP-39)
  • Subcutaneous implantation in rabbits and rats (ISO-10993, USP-39)
  • Intravenous test in rats
  • Abnormal toxicity tests/ Undue toxicity
  • Acute Pathogenicity tests (EPA)
  • Erythropoietin test
  • Insulin bio identity test/ Insulin potency test (USP 121)

   

Sub-acute/ Sub-chronic studies/ long term studies

  • Repeated Dose 14 Day/28 day/90 day toxicity study (Oral/Dermal/Inhalation) (OECD)
  • Chronic 180 days to 1 year toxicity study (Oral/Dermal/Inhalation) (OECD)
  • Carcinogenicity Studies (Rodents/ Non-Rodents) (OECD)
  • Prenatal/Postnatal Developmental Toxicity Study (OECD)
  • Multigenerational Toxicity studies (OECD)
  • Systemic Toxicity as per ISO-10993
  • Implantation studies as per ISO-10993-6 (Subcutaneous/Intramuscular/Bone)

   

Genotoxicity Studies

  • Bacterial Reverse Mutation Test (OECD 471/ISO 10993-3)
  • In-vitro Mammalian Chromosomal Aberration Test (OECD 473/ISO 10993-3)
  • In-vivo Mammalian Chromosomal Aberration Test (OECD 475)
  • In-vitro Mammalian Cell Gene Mutation Test (OECD 476/ISO 10993-3)